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Article

Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms.

Schizophrenia bulletin - 1 Jul 2007

Benes Francine M

Abstract excerpt

The endophenotype is a construct that has utility for the study of postmortem brains from patients with psychotic disorders. By identifying networks of genes that show changes in expression within specific neuronal populations implicated in the pathophysiology of schizophrenia and bipolar disorder, it may be possible to move toward understanding these disorders at the cellular and molecular levels. The ultimate...

Topics

Amygdala
Antioxidants
Bipolar Disorder
Calcium Channels, L-Type
Down-Regulation
Hippocampus
Humans
Nerve Net
Phenotype
Schizophrenia
gamma-Aminobutyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17575303
DOI: 10.1093/schbul/sbm064
PMCID: PMC2632324

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Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms.PMID 17575303Read ↗

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Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) StudySemantic proximity Read ↗

Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis.Semantic proximity Read ↗

Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part II: Cognition, neuroimaging and geneticsSemantic proximity Read ↗

[Endophenotype--a new concept for biological characterization of psychiatric disorders].Semantic proximity Read ↗

The endophenotype concept in psychiatry: etymology and strategic intentions.Semantic proximity Read ↗

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