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Article

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

Cancer research - 15 Jun 2007

Malyukova Alena, Dohda Takeaki, von der Lehr Natalie, Akhoondi Shahab, Akhondi Shahab, Corcoran Martin, Heyman Mats, Spruck Charles, Grandér Dan, Lendahl Urban, Sangfelt Olle

Abstract excerpt

Notch signaling is of crucial importance in normal T-cell development and Notch 1 is frequently mutated in T-cell acute lymphoblastic leukemias (T-ALL), leading to aberrantly high Notch signaling. In this report, we determine whether T-ALL mutations occur not only in Notch1 but also in the F-box...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to F-Box Proteins

Share to F-Box-WD Repeat-Containing Protein 7

Share to Leukemia-Lymphoma, Adult T-Cell

Share to Polymorphism, Single-Stranded Conformational

Share to Receptor, Notch1

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 17575125
DOI: 10.1158/0008-5472.CAN-06-4381

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17575125-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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