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Article

Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers.

Molecular cancer therapeutics - 1 Jun 2007

Flanagan Sheryl A, Robinson Blaine W, Krokosky Christina M, Shewach Donna S

Abstract excerpt

Radiation sensitization by 2',2'-difluoro-2'-deoxycytidine (dFdCyd) has correlated with dATP depletion [dFdCDP-mediated inhibition of ribonucleotide reductase (RR)] and S-phase accumulation. We hypothesized that radiosensitization by dFdCyd is due to nucleotide misincorporations in the presence of deoxynucleotide triphosphate pool imbalances, which, if not repaired, augments cell death following irradiation. The...

Topics

Base Pair Mismatch
Cell Line, Tumor
Deoxycytidine
Humans
Mutation
RNA, Small Interfering
Radiation-Sensitizing Agents
Gemcitabine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17575114
DOI: 10.1158/1535-7163.MCT-07-0068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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