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Article

DNA mismatch repair proficiency executing 5-fluorouracil cytotoxicity in colorectal cancer cells

15 Oct 2011

Abstract excerpt

BACKGROUND: 5-fluorouracil (5FU)-based chemotherapy is the standard treatment for advanced stage colorectal cancer (CRC) patients. Several groups including ours have reported that stage II-III colorectal cancer patients whose tumors retain DNA Mismatch repair (MMR) function derive a benefit from 5FU, but patients with tumors that lost MMR function do not. Although MMR recognition of 5FU incorporated in DNA has...

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PMID: 21814034
DOI: 10.4161/cbt.12.8.17169

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