Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.

Asian journal of andrology - 1 Jan 2000

Elzinga-Tinke Jenny E, Dohle Gert R, Looijenga Leendert Hj

Abstract excerpt

Malignant testicular germ cell tumors (TGCT) are the most frequent cancers in Caucasian males (20-40 years) with an 70% increasing incidence the last 20 years, probably due to combined action of (epi)genetic and (micro)environmental factors. It is expected that TGCT have carcinoma in situ(CIS) as their common precursor, originating from an embryonic germ cell blocked in its maturation process. The overall cure...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to Early Detection of Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene-Environment Interaction

Share to Genome-Wide Association Study

Share to Neoplasms, Germ Cell and Embryonal

Share to RNA, Messenger

Share to Testicular Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25791729
DOI: 10.4103/1008-682X.148079
PMCID: PMC4430936

Genes

BAK1
DMRT1
HPGDS
KITLG
SPRY4
TERT
TEX14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.PMID 25791729Read ↗

[Carcinoma in situ of the testis: predisposition, evolution and early detection].Semantic proximity Read ↗

Epigenetic and risk factors of testicular germ cell tumors: a brief review.Semantic proximity Read ↗

Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell TumorsSemantic proximity Read ↗

Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.Semantic proximity Read ↗

Developmental model for the pathogenesis of testicular carcinoma <i>in situ</i> : genetic and environmental aspectsSemantic proximity Read ↗

Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insightsSemantic proximity Read ↗

Pathogenesis and pathobiology of testicular germ cell tumours: a view from a developmental biological perspective with guidelines for pathological diagnosticsSemantic proximity Read ↗

Evolution of Testicular Germ Cell Tumors in the Molecular Era With Histogenetic ImplicationsSemantic proximity Read ↗

Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient CareSemantic proximity Read ↗

Epigenetics and testicular germ cell tumorsSemantic proximity Read ↗

Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overviewSemantic proximity Read ↗

Decoding testicular germ cell tumors: integrating risk, biology, and biomarkers into future care.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.