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Article

Deregulation of the G1/S‐phase control in human testicular germ cell tumours

1 Jan 2003

Abstract excerpt

Deregulated cell cycle and defective genome-integrity checkpoints are among the hallmarks of cancer. Here we summarize our recent studies of key components of the GI/S machinery in normal human spermatogenesis, and their abnormalities in testicular germ cell tumours (TGCTs), with special emphasis on carcinoma in situ lesions (CIS). Our combined immunohistochemical and immunoblotting analyses of normal human adult...

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PMID: 12760379
DOI: 10.1034/j.1600-0463.2003.1110129.x

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