Article
MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11).
Biochemistry. Biokhimiia - 1 May 2007
Burmistrova O A, Goltsov A Y, Abramova L I, Kaleda V G, Orlova V A, Rogaev E I
Abstract excerpt
MicroRNAs (miRNAs) are a class of small regulatory RNAs that control a level of expression of protein encoding genes. Their role in brain pathologies is unknown. We made a first attempt to carry out a genetic study coupled with gene expression analysis of microRNA in human neuropsychiatric pathology. Presumably, at least one third of known miRNA genes are expressed in the brain. Mutations disrupting MECP2 protein...
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