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FKBP52 deficiency–conferred uterine progesterone resistance is genetic background and pregnancy stage specific

14 Jun 2007

Abstract excerpt

Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P(4)) receptor (PR) function. Using Fkbp52(-/-) mice, we show intriguing aspects of uterine P(4)/PR signaling during pregnancy. Implantation failure is the major phenotype found in these null females, which is conserved on both C57BL6/129 and CD1 backgrounds. However, P(4) supplementation rescued implantation and subsequent decidualization...

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PMID: 17571166
DOI: 10.1172/jci31622

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