Article

Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats

2017-12-21

Abstract excerpt

Impaired progesterone (P4) signaling is linked to endometrial dysfunction and infertility in women with polycystic ovary syndrome (PCOS). Here we report for the first time that elevated expression of progesterone receptor (PGR) isoforms A and B parallels increased estrogen receptor (ER) expression in PCOS-like rat uteri. The aberrant PGR-targeted gene expression in PCOS-like rats before and after implantation over...

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Literature Corpus work: a19728ea-b600-5c07-ba0c-0cbf3f3ba2b9
DOI: 10.1101/238261

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