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Article

TRAIL limits excessive host immune responses in bacterial meningitis.

The Journal of clinical investigation - 1 Jul 2007

Hoffmann Olaf, Priller Josef, Prozorovski Timour, Schulze-Topphoff Ulf, Baeva Nevena, Lunemann Jan D, Aktas Orhan, Mahrhofer Cordula, Stricker Sarah, Zipp Frauke, Weber Joerg R

Abstract excerpt

Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the host immune response. We studied antiinflammatory effects of endogenous and recombinant TRAIL (rTRAIL) in experimental meningitis. Following intrathecal application of pneumococcal cell wall, a TLR2 ligand, we found prolonged inflammation, augmented clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17571163
DOI: 10.1172/JCI30356
PMCID: PMC1888568

Genes

TLR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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