Article
TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans.
PloS one - 1 Jan 2014
Al-Kuhlani Mufadhal, Rothschild James, Rothchild James, Pal Sukumar, de la Maza Luis M, Ouburg Sander, Morré Servaas A, Dean Deborah, Ojcius David M
Abstract excerpt
The immune system eliminates Chlamydia trachomatis infection through inflammation. However, uncontrolled inflammation can enhance pathology. In mice, TNF-related apoptosis-inducing ligand receptor (TRAIL-R), known for its effects on apoptosis, also regulates inflammation. In humans, the four homologues of TRAIL-R had never been investigated for effects on inflammation. Here, we examined whether TRAIL-R regulates...
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