Article
Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.
Cell death and differentiation - 1 Oct 2007
Tan Z, Sun X, Hou F-S, Oh H-W, Hilgenberg L G W, Hol E M, van Leeuwen F W, Smith M A, O'Dowd D K, Schreiber S S
Abstract excerpt
A dinucleotide deletion in human ubiquitin (Ub) B messenger RNA leads to formation of polyubiquitin (UbB)+1, which has been implicated in neuronal cell death in Alzheimer's and other neurodegenerative diseases. Previous studies demonstrate that UbB+1 protein causes proteasome dysfunction. However, the molecular mechanism of UbB+1-mediated neuronal degeneration remains unknown. We now report that UbB+1 causes...
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