Article
Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.
The Journal of clinical investigation - 1 Oct 2010
Teekakirikul Polakit, Eminaga Seda, Toka Okan, Alcalai Ronny, Wang Libin, Wakimoto Hiroko, Nayor Matthew, Konno Tetsuo, Gorham Joshua M, Wolf Cordula M, Kim Jae B, Schmitt Joachim P, Molkentin Jefferey D, Norris Russell A, Tager Andrew M, Hoffman Stanley R, Markwald Roger R, Seidman Christine E, Seidman Jonathan G
Abstract excerpt
Mutations in sarcomere protein genes can cause hypertrophic cardiomyopathy (HCM), a disorder characterized by myocyte enlargement, fibrosis, and impaired ventricular relaxation. Here, we demonstrate that sarcomere protein gene mutations activate proliferative and profibrotic signals in non-myocyte cells to produce pathologic remodeling in HCM. Gene expression analyses of non-myocyte cells isolated from HCM mouse...
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