The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.

doi:10.1210/jc.2008-1583

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Article

The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.

The Journal of clinical endocrinology and metabolism - 1 Feb 2009

Moore Allan F, Jablonski Kathleen A, Mason Clinton C, McAteer Jarred B, Arakaki Richard F, Goldstein Barry J, Kahn Steven E, Kitabchi Abbas E, Hanson Robert L, Knowler William C, Florez Jose C

Abstract excerpt

CONTEXT: Insulin resistance is an important feature of type 2 diabetes. Ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling, and a recent meta-analysis reported a nominal association between the Q allele in the K121Q (rs1044498) single nucleotide polymorphism in its gene ENPP1 and type 2 diabetes. OBJECTIVE AND INTERVENTION: We examined the impact of this polymorphism on...

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Identifiers

PMID: 19017751
DOI: 10.1210/jc.2008-1583
PMCID: PMC2646511

Genes

ENPP1

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Related research

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The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.PMID 19017751Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals.Semantic proximity Read ↗

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.Semantic proximity Read ↗

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.Semantic proximity Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

Impact of ENPP1 K121Q on change of insulin resistance after web-based intervention in Korean men with diabetes and impaired fasting glucose.Semantic proximity Read ↗

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.Semantic proximity Read ↗

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