Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

doi:10.1053/j.ajkd.2008.07.040

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Feb 2009

De Cosmo Salvatore, Minenna Antonio, Zhang Yuan-Yuan, Thompson Ryan, Thompson Robert, Miscio Giuseppe, Vedovato Monica, Rauseo Anna, Saller Alois, Mastroianno Sandra, Pellegrini Fabio, Trevisan Roberto, Fioretto Paola, Doria Alessandro, Trischitta Vincenzo

Abstract excerpt

BACKGROUND: Insulin resistance has a role in diabetic kidney complications. The K121Q (lysine to glutamine substitution at amino acid 121, encoded by single-nucleotide polymorphism rs1044498) variant of the ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) has been associated with insulin resistance and related vascular complications in patients with type 2 diabetes (T2D) in many, although not all,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Albuminuria

Share to Amino Acid Substitution

Share to Diabetes Mellitus, Type 2

Share to ENPP1 gene

Share to Glomerular Filtration Rate

Share to Phosphoric Diester Hydrolases

Share to Polymorphism, Single Nucleotide

Share to Pyrophosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 18950909
DOI: 10.1053/j.ajkd.2008.07.040
PMCID: PMC2939986

Genes

ENPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.PMID 18950909Read ↗

Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis including 11,855 subjects.Semantic proximity Read ↗

The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.Semantic proximity Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

PC-1 amino acid variant Q121 is associated with a lower glomerular filtration rate in type 2 diabetic patients with abnormal albumin excretion rates.Semantic proximity Read ↗

Role of ENPP1 Gene Variants in the Susceptibility to Diabetic Nephropathy in Patients with type 2 Diabetes Mellitus.Semantic proximity Read ↗

[The analysis of association between ENPP1 K121Q polymorphism and risk factors of type 2 diabetes mellitus in ukrainian population].Semantic proximity Read ↗

Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes.Semantic proximity Read ↗

Association of ENPP1 (PC-1) K121Q polymorphism with obesity-related parameters in subjects with metabolic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.