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Article

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.

Diabetes - 1 Dec 2008

Baratta Roberto, Rossetti Paola, Prudente Sabrina, Barbetti Fabrizio, Sudano Dora, Nigro Angela, Farina Maria Grazia, Pellegrini Fabio, Trischitta Vincenzo, Frittitta Lucia

Abstract excerpt

OBJECTIVE: To study the role of the ENPP1 Q121 variant on glucose homeostasis in whites from Italy. RESEARCH DESIGN AND METHODS: We conducted case-control studies in 764 adults (from two independent samples of 289 nonobese and 485 obese individuals) and 240 overweight/obese children undergoing oral glucose tolerance testing (OGTT). Early-phase insulin secretion and insulin sensitivity (the insulinogenic index and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 18776139
DOI: 10.2337/db07-1830
PMCID: PMC2584144

Genes

ENPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.PMID 18776139Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention.Semantic proximity Read ↗

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites.Semantic proximity Read ↗

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.Semantic proximity Read ↗

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.Semantic proximity Read ↗

The role of K121Q ENPP1 polymorphism in diabetes mellitus and its complications.Semantic proximity Read ↗

The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population.Semantic proximity Read ↗

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

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