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Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2007

Muthumala Amal, Montgomery Hugh, Palmen Jutta, Cooper Jackie A, Humphries Steve E

Abstract excerpt

The impact of the ACE I/D polymorphism on coronary heart disease (CHD) risk is modest at most, however it may act as a modifier gene. ACE genotype was determined in 2711 healthy middle-aged men (mean age 56 years) followed for 15 years. No genotype-CHD risk association was found, but when analyzed by quartiles of systolic blood pressure (SBP), compared with II homozygotes, carriage of each additional D allele was...

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Identifiers

PMID: 17562973
DOI: 10.1161/HYPERTENSIONAHA.107.086843

Genes

ACE
LPL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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