Article
An interaction between systolic blood pressure and angiotensin-converting enzyme gene polymorphism on carotid atherosclerosis.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Nov 2002
Kawamoto Ryuichi, Kohara Katsuhiko, Tabara Yasuharu, Miki Tetsuro
Abstract excerpt
The insertion/deletion (I/D) polymorphism of the human angiotensin-converting enzyme (ACE) gene is a major determinant of circulating ACE activity, with the D allele being associated with higher ACE levels than the I allele. Thus, chronic exposure to high levels of circulating and tissue ACE may well predispose to vascular wall thickening and atherosclerosis. However, the effect of the ACE gene on carotid...
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