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Article

Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling

11 Jun 2007

Abstract excerpt

BACKGROUND: Somatic cell nuclear transfer (SCNT) requires cytoplast-mediated reprogramming of the donor nucleus. Cytoplast factors such as maturation promoting factor are implicated based on their involvement in nuclear envelope breakdown (NEBD) and premature chromosome condensation (PCC). Given prior difficulties in SCNT in primates using conventional protocols, we hypothesized that the ability of cytoplasts to...

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PMID: 17562675
DOI: 10.1093/humrep/dem136

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