Spontaneous glutamate release controls NT-3-dependent development of hippocampal calbindin-D(28k) phenotype through activation of sodium channels ex vivo.

Abstract excerpt

Functional NMDA and AMPA ionotropic glutamate receptors are expressed in embryonic hippocampal glutamatergic pyramidal neurons prior to synapse formation but their function and mechanisms of action are still unclear. At the same time, these neurons develop their calbindin-D(28k) phenotype through an activity-dependent NT-3 autocrine loop. Using single-neuron microcultures, we show here that immature pyramidal...

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