Article
The neurotrophins NT3 and BDNF induce selective specification of neuropeptide coexpression and neuronal connectivity in arcuate and periventricular hypothalamic neurons in vitro.
Neuroendocrinology - 1 Jan 2002
Petit Florence, Huicq Séverina, Gardette Robert, Epelbaum Jacques, Loudes Catherine, Kordon Claude, Faivre-Bauman Annie
Abstract excerpt
Little is known on the influence of epigenetic factors in the developing hypothalamus, a region particularly involved in neuroendocrine regulation and rich in neuropeptides. The present study evaluated the effects of neurotrophins and neuronal activity on neuronal differentiation in hypothalamic cultures sampled from either arcuate or anterior periventricular regions of 17-day-old Sprague-Dawley fetuses....
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