Article
An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jul 2007
Tamaki Shigehiro, Sanefuzi Nobuyuki, Ohgi Kazuhiko, Imai Yuichiro, Kawakami Masayoshi, Yamamoto Kazuhiko, Ishitani Akiko, Hatake Katsuhiko, Kirita Tadaaki
Abstract excerpt
BACKGROUND: Recently, a new polymorphic gene family called the major histocompatibility complex class I chain-related gene A (MICA) was discovered about 40 kb centromeric to HLA-B gene. The MICA protein, expressed on epithelial cells and many kinds of tumor cells, serves to regulate immune function. The MICA protein is thought to activate immune function on mucosal tissue by binding to NKG2D which is expressed on...
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