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MICA A5.1 homozygous genotype is associated with a risk for early-onset oral cancer.

Oral oncology - 1 May 2021

Tani Ryouji, Ito Nanako, Matsui Kensaku, Yamasaki Sachiko, Hamada Atsuko, Tokumaru Koichiro, Toratani Shigeaki, Okamoto Tetsuji

Abstract excerpt

OBJECTIVES: Genetic predisposition is reportedly involved in early-onset oral cancer, although the genetic basis of this cancer remains unclear. The major histocompatibility complex class I-related chain A (MICA) plays a crucial role in eliminating malignant tumors by activating NKG2D, the natural killer (NK) receptor. MICA polymorphism might affect its binding to NKG2D. We aimed to find whether MICA gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33730629
DOI: 10.1016/j.oraloncology.2021.105256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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