Article
The increase in the frequency of MICA gene A6 allele in oral squamous cell carcinoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jul 2002
Chung-Ji Liu, Yann-Jinn Lee, Hsin-Fu Liu, Ching-Wen Dang, Che-Shoa Chang, Yi-Shing Leu, Kuo-Wei Chang
Abstract excerpt
BACKGROUND: Oral squamous cell carcinoma (OSCC) was reported to be associated with immune function. The MICA (MHC class I chain-related gene A) is expressed by keratinocytes and other epithelial cells, and its encoded protein interacts with gamma/delta T cells localized in submucosa. The MICA also influences the heat shock protein function. We speculated that the alterations of MICA might influence the...
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