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Article

X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter†

9 Jun 2007

Abstract excerpt

UNLABELLED: The X protein of hepatitis B virus (HBx) is essential for transactivation of hepatitis B viral and host cellular genes. It has been specifically implicated in the development of hepatocellular carcinoma; however, the molecular mechanism remains unknown. Telomeres, the DNA-protein complexes at the ends of eukaryotic chromosomes, protect chromosomes from degradation at the terminal regions, fusion with...

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Identifiers

PMID: 17559154
DOI: 10.1002/hep.21675

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