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Article

Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus.

Nature neuroscience - 1 Jul 2007

Tsetsenis Theodoros, Ma Xiao-Hong, Lo Iacono Luisa, Beck Sheryl G, Gross Cornelius

Abstract excerpt

Serotonin receptor 1A knockout (Htr1a(KO)) mice show increased anxiety-related behavior in tests measuring innate avoidance. Here we demonstrate that Htr1a(KO) mice show enhanced fear conditioning to ambiguous conditioned stimuli, a hallmark of human anxiety. To examine the involvement of specific forebrain circuits in this phenotype, we developed a pharmacogenetic technique for the rapid tissue- and cell...

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Identifiers

PMID: 17558402
DOI: 10.1038/nn1919
PMCID: PMC2836794

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