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Article

FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.

Human molecular genetics - 15 Feb 2008

Berry Fred B, Skarie Jonathan M, Mirzayans Farideh, Fortin Yannick, Hudson Thomas J, Raymond Vincent, Link Brian A, Walter Michael A

Abstract excerpt

Mutations in the human FOXC1 transcription factor gene underlie Axenfeld-Rieger (AR) syndrome, a disorder characterized by anterior segment malformations in the eye and glaucoma. Through the use of an inducible FOXC1 protein, along with an intermediate protein synthesis blocker, we have determined direct targets of FOXC1 transcriptional regulation. FOXC1 regulates the expression of FOXO1A and binds to a conserved...

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Source

Identifiers

PMID: 17993506
DOI: 10.1093/hmg/ddm326

Genes

FOXC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.PMID 17993506Read ↗

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