Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica.

PloS one - 1 Jan 2012

Koenigsknecht Mark J, Lambrecht Jennifer A, Fenlon Luke A, Downs Diana M

Abstract excerpt

Phosphoribosylamine (PRA) is an intermediate in the biosynthetic pathway that is common to thiamine and purines. Glutamine phosphoribosyl pyrophosphate (PRPP) amidotransferase is the product of the purF gene in Salmonella enterica and catalyzes the synthesis of PRA from PRPP and glutamine. Strains lacking PurF require exogenous addition of purines for growth. However, under some growth conditions or with specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Histidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Networks and Pathways

Share to Models, Chemical

Share to Operon

Share to Purines

Share to Salmonella enterica

Share to Thiamine

Source

Open in PubMed Open full text

Identifiers

PMID: 23133571
DOI: 10.1371/journal.pone.0048207
PMCID: PMC3485032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica.PMID 23133571Read ↗

Mutations in the tryptophan operon allow PurF-independent thiamine synthesis by altering flux in vivo.Semantic proximity Read ↗

Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica.Semantic proximity Read ↗

Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica.Semantic proximity Read ↗

Plasticity in the purine-thiamine metabolic network of Salmonella.Semantic proximity Read ↗

Pyridoxal and α-Ketoglutarate Independently Improve Function of Saccharomyces cerevisiae Thi5 in the Metabolic Network of Salmonella enterica.Semantic proximity Read ↗

Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica.Semantic proximity Read ↗

Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica.Semantic proximity Read ↗

Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium.Semantic proximity Read ↗

Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica.Semantic proximity Read ↗

Defects in pyruvate kinase cause a conditional increase of thiamine synthesis in Salmonella typhimurium.Semantic proximity Read ↗

Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase.Semantic proximity Read ↗

Endogenously generated 2-aminoacrylate inhibits motility in Salmonella enterica.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.