Article
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo.
Science signaling - 4 Aug 2009
Schleicher Michael, Yu Jun, Murata Takahisa, Derakhshan Berhad, Atochin Dimitriy, Qian Li, Kashiwagi Satoshi, Di Lorenzo Annarita, Harrison Kenneth D, Huang Paul L, Sessa William C
Abstract excerpt
Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase (eNOS) as an Akt1 substrate by generating Akt1-deficient mice (Akt1(-/-) mice) carrying knock-in mutations (serine to aspartate or serine to alanine substitutions) of the critical Akt1 phosphorylation site on eNOS (serine 1176)...
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