Article
High serum levels of BAFF, APRIL, and TACI in common variable immunodeficiency.
Clinical immunology (Orlando, Fla.) - 1 Aug 2007
Knight Adina K, Radigan Lin, Marron Thomas, Langs Allison, Zhang Li, Cunningham-Rundles Charlotte
Abstract excerpt
Common variable immunodeficiency (CVID) is characterized by low levels of immune globulins and lack of antibody. Mutations in transmembrane activator and calcium-modulating cyclophilin ligand (TACI), are found in 8-10%, associated with autoimmunity and splenomegaly. Some patients with mutations had increased serum levels of TACI. Because of this, and the prevalence of autoimmunity, splenomegaly, and...
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