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Article

Heterozygosity of genes on the sex chromosome regulates <i>Candida albicans</i> virulence

1 Jun 2007

Abstract excerpt

In the mouse model for systemic infection, natural a/alpha strains of C. albicans are more virulent and more competitive than their spontaneous MTL-homozygous offspring, which arise primarily by loss of one chromosome 5 homologue followed by duplication of the retained homologue (uniparental disomy). Deletion of either the a or alpha copy of the MTL locus of natural a/alpha strains results in a small decrease in...

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PMID: 17555440
DOI: 10.1111/j.1365-2958.2007.05759.x

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