Article
Semliki Forest Virus Nonstructural Protein 2 Is Involved in Suppression of the Type I Interferon Response
7 Jun 2007
Abstract excerpt
The type I interferons (IFNs) are potent mediators of antiviral immunity, and many viruses have developed means to block their expression or their effects. Semliki Forest virus (SFV) infection induces rapid and profound silencing of host cell gene expression, a process believed to be important for the inhibition of the IFN response. In SFV-infected cells, a large proportion of the nonstructural protein nsp2 is...
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