Article
Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2007
Levin Albert M, Ray Anna M, Zuhlke Kimberly A, Douglas Julie A, Cooney Kathleen A
Abstract excerpt
Many studies have established that loss of heterozygosity and/or altered expression of the fragile histidine triad (FHIT) gene is a common event in a number of tumor types including prostate carcinoma. Encompassing the most active fragile site in the human genome, FRA3B, FHIT has become the model fragile site-associated tumor suppressor gene. In a recent study, linkage and association between germline genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.