Article
The androgen receptor CAG and GGN repeat polymorphisms and prostate cancer susceptibility in African-American men: results from the Flint Men's Health Study.
Journal of human genetics - 1 Jan 2008
Lange Ethan M, Sarma Aruna V, Ray Anna, Wang Yunfei, Ho Lindsey A, Anderson Sarah A, Cunningham Julie M, Cooney Kathleen A
Abstract excerpt
Repeat lengths of the CAG and GGN microsatellites in exon 1 of the androgen receptor (AR) gene have been hypothesized to be associated with prostate cancer risk. In vitro studies have showed an inverse association between AR CAG and GGN repeat length and activity levels of the AR product. It is known that men of African descent have a higher incidence of and greater mortality from prostate cancer than men of...
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