Article
Risk of early-onset prostate cancer in relation to germ line polymorphisms of the vitamin D receptor.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2004
Oakley-Girvan Ingrid, Feldman David, Eccleshall T Ross, Gallagher Richard P, Wu Anna H, Kolonel Laurence N, Halpern Jerry, Balise Raymond R, West Dee W, Paffenbarger Ralph S, Whittemore Alice S
Abstract excerpt
Vitamin D inhibits prostate cancer cell growth, angiogenesis, and metastasis. These actions are mediated by the vitamin D receptor. We examined associations between prostate cancer risk and five polymorphisms in the VDR gene: four single nucleotide polymorphisms (FokI, BsmI, ApaI, and TaqI restriction sites) and the polyadenylic acid microsatellite. Specifically, we genotyped population-based samples of young...
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