Article
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
PLoS pathogens - 1 Jul 2009
Pandey Amit K, Yang Yibin, Jiang Zhaozhao, Fortune Sarah M, Coulombe Francois, Behr Marcel A, Fitzgerald Katherine A, Sassetti Christopher M, Kelliher Michelle A
Abstract excerpt
While the recognition of microbial infection often occurs at the cell surface via Toll-like receptors, the cytosol of the cell is also under surveillance for microbial products that breach the cell membrane. An important outcome of cytosolic recognition is the induction of IFNalpha and IFNbeta, which are critical mediators of immunity against both bacteria and viruses. Like many intracellular pathogens, a...
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