Article
Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer.
Clinical endocrinology - 1 Aug 2007
Lemos Manuel C, Carrilho Francisco, Rodrigues Fernando, Coutinho Eduarda, Gomes Leonor, Carvalheiro Manuela, Regateiro Fernando J
Abstract excerpt
OBJECTIVE: Xenobiotic-metabolizing enzymes are widely polymorphic and confer interindividual variation in the ability to detoxify carcinogens or to activate pro-carcinogens. A common polymorphism of cytochrome P450 2D6 (CYP2D6) results in lack of enzyme activity and has been associated with an al...
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