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Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma.

Archives of toxicology - 1 Dec 2016

Pellé Lucia, Cipollini Monica, Tremmel Roman, Romei Cristina, Figlioli Gisella, Gemignani Federica, Melaiu Ombretta, De Santi Chiara, Barone Elisa, Elisei Rossella, Seiser Eric, Innocenti Federico, Zanger Ulrich M, Landi Stefano

Abstract excerpt

Differentiated thyroid carcinoma (DTC) results from complex interactions between genetic and environmental factors. Known etiological factors include exposure to ionizing radiations, previous thyroid diseases, and hormone factors. It has been speculated that dietary acrylamide (AA) formed in diverse foods following the Maillard's reaction could be a contributing factor for DTC in humans. Upon absorption, AA is...

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PMID: 26783003
DOI: 10.1007/s00204-016-1660-8

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