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Article

KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription.

Cell cycle (Georgetown, Tex.) - 1 Feb 2010

Urvalek Alison M, Wang Xianhui, Lu Heng, Zhao Jihe

Abstract excerpt

Krüppel-like factor 8 (KLF8) regulates critical cellular processes including cell cycle progression, transformation, epithelial-to-mesenchymal transition, migration and invasion by either repressing or activating target gene promoters. As a repressor, KLF8 recruits the CtBP co-repressor via its PVDLS repression motif. However, how KLF8 acts as an activator has not been determined. Here we report the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20107328
DOI: 10.4161/cc.9.3.10606
PMCID: PMC2888133

Genes

KLF8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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