Article
PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes mellitus. Results from the genetics of atherosclerotic disease Mexican study.
Immunobiology - 1 Oct 2017
Monroy-Muñoz Irma Eloisa, Angeles-Martinez Javier, Posadas-Sánchez Rosalinda, Villarreal-Molina Teresa, Alvarez-León Edith, Flores-Dominguez Carmina, Cardoso-Saldaña Guillermo, Medina-Urrutia Aida, Juárez-Rojas Juan Gabriel, Posadas-Romero Carlos, Alarcon Gilberto Vargas
Abstract excerpt
The secretory phospholipase A2 II A (sPLA2-IIA) encoded by PLA2G2A gene hydrolyzes phospholipids liberating free fatty acids (FFAs) and lysophospholipids. If lipolysis exceeds lipogenesis, the free fatty acids undergo a continuous release into circulation. A sustained excessive increase in this release contributes to metabolic disease. The aim of the present study was to evaluate the role of PLA2G2A gene...
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