Article
Blockade of monocyte chemoattractant protein-1 by adenoviral gene transfer inhibits experimental vein graft neointimal formation.
Journal of vascular surgery - 1 Jun 2007
Tatewaki Hideki, Egashira Kensuke, Kimura Satoshi, Nishida Takahiro, Morita Shigeki, Tominaga Ryuji
Abstract excerpt
BACKGROUND: Clinical outcome of vascular bypass surgery using autologous vein graft is limited by neointimal formation associated with vein graft failure. Because inflammatory changes are one of the main pathologic features of vein graft failure, monocyte chemoattractant protein-1 (MCP-1) might therefore underlie in the mechanism of vein graft failure. There is no direct evidence, however, that shows the benefits...
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