Article
Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo.
Gene therapy - 1 Dec 2001
Skelly C L, Curi M A, Meyerson S L, Woo D H, Hari D, Vosicky J E, Advani S J, Mauceri H J, Glagov S, Roizman B, Weichselbaum R R, Schwartz L B
Abstract excerpt
Neointimal hyperplasia resulting from vascular smooth muscle cell (SMC) proliferation and luminal migration is the major cause of autologous vein graft failure following vascular coronary or peripheral bypass surgery. Strategies to attenuate SMC proliferation by the delivery of oligonucleotides or genes controlling cell division rely on the use of high concentrations of vectors, and require pre-emptive disruption...
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