Article
Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast cancer families.
Breast cancer research and treatment - 1 Apr 2008
Arcand Suzanna L, Maugard Christine M, Ghadirian Parviz, Robidoux André, Perret Chantal, Zhang Phil, Fafard Eve, Mes-Masson Anne-Marie, Foulkes William D, Provencher Diane, Narod Steven A, Tonin Patricia N
Abstract excerpt
About 40% of French Canadian breast and/or ovarian cancer families harbor germline BRCA1 or BRCA1 mutations where common mutations account for about 84% of all mutations identified in cancer families. Within a series of BRCA1 and BRCA2 mutation-negative families, a germline TP53 13398 G>A (Arg213Gln) mutation was identified, which was selected for mutation analysis in this gene because of a family history...
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