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Article

Germline TP53 mutational spectrum in French Canadians with breast cancer.

BMC medical genetics - 12 Apr 2015

Arcand Suzanna L, Akbari Mohammed R, Mes-Masson Anne-Marie, Provencher Diane, Foulkes William D, Narod Steven A, Tonin Patricia N

Abstract excerpt

BACKGROUND: Specific germline mutations in the hereditary breast-ovarian cancer susceptibility (HBC/HBOC) genes, BRCA1, BRCA2 and PALB2, have been shown to recur in French Canadians of Quebec, Canada, and this has been attributed to common ancestors. Germline TP53 mutation carriers are known to segregate in Li-Fraumeni syndrome families, which feature young age of onset breast cancer. We have reported rare TP53...

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Source

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Identifiers

PMID: 25925845
DOI: 10.1186/s12881-015-0169-y
PMCID: PMC4436120

Genes

BRCA1
BRCA2
PALB2

Variants

Provenance

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