Article

Germline mutations of p53 tumor gene linked to Li-Fraumeni syndrome (LFS) are associated with an increased risk of cancer

2022-11-18

Abstract excerpt

Choroid plexus carcinomas (CPCs) are rare pediatric tumors often associated with Li-Fraumeni Syndrome (LFS). In LFS, TP53 mutations are involved. A germline mutation in the TP53 gene has been found in about three-quarters of families with Li-Fraumeni syndrome and one-quarter of families with Li-Fraumeni-like syndrome. LFS is a complex predisposition to inherited cancer associated with early cancer in different tis...

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Literature Corpus work: 21fc33da-c91f-5ecb-850b-cee45ae906fc
DOI: 10.21203/rs.3.rs-2267701/v1

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