Article
Dynamics of 103K/N and 184M/V HIV-1 drug resistant populations: relative comparison in plasma virus RNA versus CD45RO+T cell proviral DNA.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jul 2007
Jakobsen M R, Tolstrup M, Bertelsen L, Laursen A, Obel N, Ostergaard L, Mohey R
Abstract excerpt
BACKGROUND: Viral populations defined by 103K/N and 184M/V as linked or single mutations in the HIV-1 reverse transcriptase gene were investigated in plasma samples and compared with previous findings in the CD45RO(+)T cell compartment. OBJECTIVE: To develop an ARMS assay for plasma virions and to investigate the expression of resistance mutations (103N and 184V) and dynamic interactions between proviral DNA and...
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