Article
Detection and quantification of proviral HIV-1 184 M/V in circulating CD4(+) T cells of patients on HAART with a viremia less than 1,000 copies/ml.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2005
Mohey Rajesh, Jørgensen Louise B, Møller Bjarne K, Black Finn T, Kjems Jørgen, Obel Niels
Abstract excerpt
BACKGROUND: Highly active anti-retroviral therapy (HAART) effectively reduces HIV replication but does not completely hinder it. Sub-optimal therapy leads to HIV resistance to the drugs administered. However, the role of low-level viremia (viral-load less than 1,000 copies/ml) on mutation genesis and incorporation of resistant forms in the long-lived CD4(+) T cellular DNA compartment is not clear. OBJECTIVE: To...
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