Article
Involvement of host cellular multivesicular body functions in hepatitis B virus budding.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2007
Watanabe Tokiko, Sorensen Ericka M, Naito Akira, Schott Meghan, Kim Seungtaek, Ahlquist Paul
Abstract excerpt
Hepatitis B virus (HBV) is a major human pathogen that chronically infects approximately 350 million people, causing liver disease and liver cancer. HBV virions bud into an endoplasmic reticulum (ER)-associated intracellular compartment, but the mechanisms of HBV assembly, budding, and release remain poorly understood. Budding of retroviruses and some other enveloped RNA viruses from plasma membranes requires...
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