Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2.

Journal of virology - 1 Oct 2012

Liu Ling, Sutton Jessica, Woodruff Elvin, Villalta Fernando, Spearman Paul, Dong Xinhong

Abstract excerpt

Adaptor protein complex 3 (AP-3) is a heterotetramer that is involved in signal-mediated protein sorting to endosomal-lysosomal organelles. AP-3 deficiency in humans, induced by mutations in the AP3B1 gene, which encodes the β3A subunit of the AP-3 complex, results in Hermansky-Pudlak syndrome 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clathrin
Share to Endocytosis
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Hermanski-Pudlak Syndrome

Share to Virus Assembly

Share to Virus Release

Source

Open in PubMed Open full text

Identifiers

PMID: 22875976
DOI: 10.1128/JVI.00544-12
PMCID: PMC3457180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22875976-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2.PMID 22875976Read ↗

Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2.Semantic proximity Read ↗

Nonsense mutations in ADTB3A cause complete deficiency of the beta3A subunit of adaptor complex-3 and severe Hermansky-Pudlak syndrome type 2.Semantic proximity Read ↗

The clathrin adaptor complex AP-1 binds HIV-1 and MLV Gag and facilitates their budding.Semantic proximity Read ↗

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.Semantic proximity Read ↗

Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1.Semantic proximity Read ↗

Novel AP3B1 compound heterozygous mutations in a Japanese patient with Hermansky-Pudlak syndrome type 2.Semantic proximity Read ↗

Assembly of the Biogenesis of Lysosome-related Organelles Complex-3 (BLOC-3) and Its Interaction with Rab9Semantic proximity Read ↗

Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse.Semantic proximity Read ↗

Hermansky-Pudlak syndrome type 2: Aberrant pre-mRNA splicing and mislocalization of granule proteins in neutrophils.Semantic proximity Read ↗

Novel insights from adaptor protein 3 complex deficiencySemantic proximity Read ↗

BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.Semantic proximity Read ↗

Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.