Article
Haplotype inference in general pedigrees using the cluster variation method.
Genetics - 1 Oct 2007
Albers Cornelis A, Heskes Tom, Kappen Hilbert J
Abstract excerpt
We present CVMHAPLO, a probabilistic method for haplotyping in general pedigrees with many markers. CVMHAPLO reconstructs the haplotypes by assigning in every iteration a fixed number of the ordered genotypes with the highest marginal probability, conditioned on the marker data and ordered genotypes assigned in previous iterations. CVMHAPLO makes use of the cluster variation method (CVM) to efficiently estimate...
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